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Full Chemical Name: JWH-018
Systematic IUPAC Name Naphthalen-1-yl-(1-pentylindol-3-yl)methanone
CAS Number 209414-07-3
ChemSpider Number 8558143
Molecular Formula C24H23NO
Molecular Mass 341.45 g/mol
JWH-018 (1-pentyl-3-(1-naphthoyl)indole) or AM-678 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors.
with some selectivity for CB2.
It produces effects in animals similar to those of tetrahydrocannabinol (THC).
This is to say, As a full agonist at both the CB1 and CB2 cannabinoid receptors, this chemical compound is classified as an analgesic medication.
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These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones .
2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling.
In short, As the cause is poorly understood in chronic pain states, more research and development should be done before we can realize the therapeutic potential of this class of biologic compounds.
What is JWH 018?
JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively.
However, for a CB1:CB2 ratio of 3.06.1 Its effects on suppression of spontaneous activity, maximum possible antinociceptive effect in the tail-flick .
Meanwhile, It is a research chemical that belongs to the naphthoylindole family.
Further, JWH-081 as all the other research chemicals in the JWH group is a synthetic cannabinoid with analgesic effects.
Subsequently, Its full chemical name is 4-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanone with chemical formula as C25H25NO2 and molecular mass 371.47 g/mol..
In conclusion, JWH-018 usage is detect in urine using “spice” screening immunoassays from several manufacturers focused on both the parent drug and its omega-hydroxy and carboxyl metabolites.